罗伯特博士（文森特·普莱斯 Vincent Price 饰）一直致力于在中美洲研究细菌，长此以往，罗伯特竟然在误打误撞之中获得了超强的免疫能力。一场非常可怕的瘟疫席卷了全球，地球上所有的生物都未能够幸免于难，除了罗伯特博士外，此时此刻，他成为了地球上的最后一个人类。
当然，罗伯特博士并不“孤独”，因为那些感染了瘟疫而死去的人们，他们的尸体会在午夜化身成为可怕的丧尸，爬出坟墓，聚集在罗伯特博士的居所周围，能够让他们暂停行动的，只有阳光。一次偶然中，罗伯特博士震惊的得知，他并非最后的幸存者，在世界的某一处，还有着一些和他一样的人类也在灾难中苦苦挣扎。
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