罗伯特博士(文森特·普莱斯 Vincent Price 饰)一直致力于在中美洲研究细菌,长此以往,罗伯特竟然在误打误撞之中获得了超强的免疫能力。一场非常可怕的瘟疫席卷了全球,地球上所有的生物都未能够幸免于难,除了罗伯特博士外,此时此刻,他成为了地球上的最后一个人类。
当然,罗伯特博士并不“孤独”,因为那些感染了瘟疫而死去的人们,他们的尸体会在午夜化身成为可怕的丧尸,爬出坟墓,聚集在罗伯特博士的居所周围,能够让他们暂停行动的,只有阳光。一次偶然中,罗伯特博士震惊的得知,他并非最后的幸存者,在世界的某一处,还有着一些和他一样的人类也在灾难中苦苦挣扎。
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